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What is CRISPR?

CRISPR is the abbreviation for Clustered Regulatory Interspersed Short Palindromic Repeats,and was discovered as an ancient prokaryotic immune system, protecting bacteria against viral infections. The CRISPR system allow scientist to alter the genome of any organism.

How does it work?

CRISPR allows the recognition of specific DNA and RNA sequences by Cas, a protein that cleaves DNA. Subsequent repair of the broken DNA allows precise modification of the target site.
CRISPR can be envisioned as a cut-and-paste toolbox that enables scientist to precisely and selectively edit DNA and RNA sequences.

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Genome engineering through CRISPR is offering many new and exciting possibilities for biomedical research as well as opening up potential clinical applications in the future. To fully take advantage of CRISPR and its applications the Cancer Center Amsterdam (CCA) has initiated the CRISPR Platform and assigned a CRISPR Consultant.


To advance the implementation of this state-of-the-art technology and quickly overcome its challenges, the CRISPR Platform is bringing Amsterdam UMC researchers interested in CRISPR together. By organizing regular user meetings and by hosting an online community platform, researchers can easily interact to solve problems and share information on all issues related to CRISPR.

Latest news

New Tools: a watchdog for translocations and off-target editing

CRISPector algorithm can spot potential off-target modifications and quantify translocations. Amit, I. et al. (2021) CRISPECTOR provides accurate estimation of
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New Tools: CRISPR C>G, G>C base editor

Chen, L. et al. (2021) Programmable genome editing with CRISPR-Cas9-directed base excision repair proteins Nature Communications.DOI: 10.1038/s41467-021-21559-9 Keywords: CRISPR, Base
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We have established an online community platform for all CRISPR users of the Amsterdam UMC. Please register or sign in to ask questions about CRISPR technology and discuss your problems and ideas.
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We regularly organize courses for AUMC PhD students and PostDocs. Please register to participate.
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Tools and links

We have assembled a selection of useful CRISPR tools and links.
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