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What is CRISPR?

CRISPR is the abbreviation for Clustered Regulatory Interspersed Short Palindromic Repeats,and was discovered as an ancient prokaryotic immune system, protecting bacteria against viral infections. The CRISPR system allow scientist to alter the genome of any organism.

How does it work?

CRISPR allows the recognition of specific DNA and RNA sequences by Cas, a protein that cleaves DNA. Subsequent repair of the broken DNA allows precise modification of the target site.
CRISPR can be envisioned as a cut-and-paste toolbox that enables scientist to precisely and selectively edit DNA and RNA sequences.

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Opportunities

Genome engineering through CRISPR is offering many new and exciting possibilities for biomedical research as well as opening up potential clinical applications in the future. To fully take advantage of CRISPR and its applications the Cancer Center Amsterdam (CCA) has initiated the CRISPR Platform and assigned a CRISPR Consultant.

Challenges

To advance the implementation of this state-of-the-art technology and quickly overcome its challenges, the CRISPR Platform is bringing Amsterdam UMC researchers interested in CRISPR together. By organizing regular user meetings and by hosting an online community platform, researchers can easily interact to solve problems and share information on all issues related to CRISPR.

Latest news

CRISPR pioneers Emmanuelle Charpentier and Jennifer A. Doudna receive the Nobel Prize in Chemistry 2020

For more information: https://www.kva.se/en/pressrum/pressmeddelanden/nobelpriset-i-kemi-2020 Keywords: CRISPR, Cas9, Nobel Prize
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Scientific Advances: CRISPR screen identifies gene set in cancer cells to escape cytotoxic T lymphocytes

From the lab of Jason Moffat, Nature has published a study in which the mouse (m)TKO whole genome CRISPR library
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Forum

We have established an online community platform for all CRISPR users of the Amsterdam UMC. Please register or sign in to ask questions about CRISPR technology and discuss your problems and ideas.
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Courses

We regularly organize courses for AUMC PhD students and PostDocs. Please register to participate.
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Tools and links

We have assembled a selection of useful CRISPR tools and links.
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