Scientific Advances: CRISPR screen identifies gene set in cancer cells to escape cytotoxic T lymphocytes

From the lab of Jason Moffat, Nature has published a study in which the mouse (m)TKO whole genome CRISPR library is used to identify genes that support tumor cells to escape from cytotoxic T lymphocytes. 

Reference: Lawson, K.A., Sousa, C.M., Zhang, X. et al. (2020) Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Nature 586, 120–126.

Keywords: CRISPR screen, Cancer, Cytotoxic T cells, Immune Evasion

Questions? Email:

CRISPR and Beyond: Perturbations at Scale to Understand Genomes (Virtual Conference)

22 – 25 September 2020. Wellcome Genome Campus, UK.

Starting Tuesday September 22 a four-day virtual conference will take place on CRISPR genome editing organized at the Wellcome Genome Campus UK. Topics range from the development of new and improved CRISPR tools for genome modifications to the applications of CRISPR to dissect biomolecular functions. The registration deadline is September 14, 2020, registration fees are £50 for students and £100 for academics.

For more information:

Keywords: Virtual Conference, CRISPR tools, CRISPR Screens, DNA Damage Response

Questions? Email:

Scientific Advances: Synthetic immunomodulation with a CRISPR super-repressor in vivo

The clinical implementation of gene therapy is complicated by a potential immune response to the vectors used for in vivo delivery. In a recent paper by Moghadan et al. CRISPR-mediated transcriptional repression is exploited to dampen the immune response against AAV in vivo.

Reference: Moghadam, F., LeGraw, R., Velazquez, J.J. et al. (2020) Synthetic immunomodulation with a CRISPR super-repressor in vivo. Nat Cell Biol 22, 1143–1154.

Keywords: Immunosuppression, Gene therapy, CRISPR, Myd88

Questions? Email: