From the lab of Jason Moffat, Nature has published a study in which the mouse (m)TKO whole genome CRISPR library is used to identify genes that support tumor cells to escape from cytotoxic T lymphocytes.
Reference: Lawson, K.A., Sousa, C.M., Zhang, X. et al. (2020) Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Nature 586, 120–126. https://doi.org/10.1038/s41586-020-2746-2
Keywords: CRISPR screen, Cancer, Cytotoxic T cells, Immune Evasion
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