In light of a pending second COVID-19 wave, an on-site diagnostic test that is fast and accurate could make a real difference in preventing the spread of SARS-CoV-2.
In the following manuscript, uploaded to the medRxiv server before peer review, a multicenter study involving the Amsterdam UMC, Leiden UMC, and OLVG Amsterdam is presented showing that a Cas12-based diagnostic test called DETECTR is as effective as current PCR-based COVID-19 testing. However in comparison to current standards, DETECTR works faster and can be deployed onsite as a point of care test.
Pre-Print: Brandsma & Verhagen et al. Rapid, sensitive and specific SARS coronavirus-2 detection: a multi-center comparison between standard qRT-PCR and CRISPR based DETECTR. medRxiv (2020). https://doi.org/10.1101/2020.07.27.20147249
For more information on CRISPR Diagnostics see our news item on the comprehensive review by Van Dongen et al. in Biosensors and Bioelectronics.
Keywords: CRISPR-Dx, COVID-19, DETECTR, Cas12
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