April 11-24 Genome wide CRISPR Screens

Simoneschi, D. et al. CRL4AMBRA1 is a master regulator of D-type cyclins. Nature https://doi.org/10.1038/s41586-021-03445-y

Hayman, T.J., et al. STING enhances cell death through regulation of reactive oxygen species and DNA damage. Nat. Comm. https://doi.org/10.1038/s41467-021-22572-8

Lee, D-h., et al. Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells. Cancer Letters https://doi.org/10.1016/j.canlet.2021.04.006

Jung, H.R., et al. CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers. Oncogene https://doi.org/10.1038/s41388-021-01777-7 Xu, Z. et al. CHK2 inhibition provides a strategy to suppress hematological toxicity from PARP inhibitors. Mol. Cancer Res. DOI: 10.1158/1541-7786.MCR-20-0791