Editing the DNA of mitochondria has proven problematic due to lack of suitable targeting sites and delivery challenges. Some progress has recently been reported.

For more information see:
Wang, B., et al. (2021) CRISPR/Cas9-mediated mutagenesis at micro-homologous regions of human mitochondrial genome, Science China Life Sciences. DOI: 10.1007/s11427-020-1819-8
Dan, J. et al. (2021) Expanding the Toolbox and Targets for Gene Editing, Trends in Molecular Medicine. DOI: 10.1016/j.molmed.2020.12.005

Keywords: CRISPR, gene editing, mitochondria

Questions? Email: crispr@amsterdamumc.nl