In the lab of David Liu, a CRISPR base editor was successfully applied to correct mutations in the β-globin gene HBB.
Newby, G.A., Yen, J.S., Woodard, K.J. et al. (2021) Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature. https://doi.org/10.1038/s41586-021-03609-w
Keywords: CRISPR, Base Editors, sickle cell disease
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